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Qingdao Conqinphi Environmental Technology Group Co., Ltd. proudly presents our Pharmaceutical Grade Multi-effect Evaporation Concentration Equipment for API Purification. Backed by a 10,000-30,000 sqm factory and over 8 years of specialized manufacturing experience, we deliver high-efficiency evaporation solutions tailored for the strict demands of active pharmaceutical ingredient (API) purification. Our multi-effect design significantly reduces energy consumption while ensuring product quality meets cGMP standards. With an annual export value of US$10-50 million, our equipment is trusted by clients across North America, Europe, Southeast Asia and beyond.
The core principle of multi-effect evaporation is to reuse vapor from one effect as heating medium for the next, achieving energy savings of up to 60% compared to single-effect evaporators. This pharmaceutical-grade unit is constructed from high-quality stainless steel (316L/304) with electropolished surfaces, meeting FDA and EU GMP requirements for cleanability and corrosion resistance. It is ideal for concentrating heat-sensitive APIs, herbal extracts, and pharmaceutical solutions under vacuum conditions.
Key Features & Technical Specifications
- Multi-effect design (2-7 effects): Maximizes energy efficiency; steam consumption reduces by approximately 20% per additional effect.
- Vacuum operation: Low-temperature evaporation protects thermal-sensitive APIs from degradation.
- Sanitary construction: All product-contact surfaces are 316L SS with Ra ≤ 0.5 μm; no dead corners for easy CIP/SIP.
- PLC/HMI automatic control: Touch-screen interface for parameter setting, data logging and alarm management (optional).
- Compact footprint: Modular design saves floor space while allowing capacity expansion.
- Versatile heating source: Compatible with steam, hot water, or thermal oil systems.
- Anti-foaming system: Integrated foam detection and suppression prevents product carryover.
| Parameter | Standard Range | Notes |
|---|---|---|
| Evaporation capacity | 100 – 5000 L/h | Customizable per client process |
| Number of effects | 2 – 7 | Higher effects = lower energy cost |
| Evaporation temperature | 40 – 120°C | Vacuum enables low-temperature operation |
| Material of construction | SS304 / SS316L | Optional lining with PTFE |
| Control system | Manual / Semi-auto / PLC | SCADA integration available |
Advantages for API Purification
- Energy savings: Multi-effect heat recovery cuts operating costs by 40-60%.
- High concentration ratios: Achieve up to 98% solid content depending on API properties.
- Gentle processing: Short residence time and low temperature preserve product activity.
- Regulatory compliance: Equipment can be designed to meet cGMP, FDA 21 CFR Part 11 and other global standards (validation documentation available).
- Scalability: From lab-scale (50 L/h) to production-scale (5000+ L/h), we provide turnkey solutions.
- Easy maintenance: Quick-opening covers, removable tube bundles and clean-in-place (CIP) nozzles reduce downtime.
Our factory in Qingdao, Shandong, spans 10,000-30,000 m² and employs 201-300 skilled workers. We have implemented quality management systems (ISO9001, ISO14000, OHSAS18001 and others) to ensure consistent product excellence. Every unit undergoes rigorous hydrostatic testing, surface finish inspection and performance verification before shipment. We offer comprehensive after-sales support, including installation guidance, commissioning, and spare parts supply.
With ports of shipment in Qingdao, we export to major markets worldwide. Our annual export value of US$10-50 million reflects the trust of international pharmaceutical companies. We are confident that our multi-effect evaporation concentration equipment will bring long-term value to your API purification process. Contact us today for a customized quotation or technical discussion.
Frequently Asked Questions (FAQ)
-
Q: What is the difference between multi-effect and single-effect evaporation?
A: Multi-effect evaporation reuses vapor from one effect as steam for the next, reducing energy consumption by 40-60%. Single-effect uses fresh steam only once, making it less efficient for large-scale API concentration. -
Q: Can this equipment handle heat-sensitive APIs?
A: Yes. The system operates under vacuum, allowing evaporation at low temperatures (as low as 40°C) to prevent thermal degradation of sensitive molecules. -
Q: What materials contact the product?
A: All wetted parts are made of 316L stainless steel with electropolished surfaces (Ra ≤ 0.5 μm). Optional PTFE or glass lining is available for corrosive media. -
Q: Is the system fully automated?
A: We offer manual, semi-automatic, and fully automatic PLC control with HMI interface. Data logging and remote monitoring can be integrated upon request. -
Q: Do you provide validation documents for GMP compliance?
A: Yes. We can supply IQ/OQ/PQ protocols, material certificates, weld maps, and surface finish reports to support your regulatory needs. -
Q: What is the typical delivery time?
A: Lead time depends on capacity and customization. Standard models ship in 30-45 days; larger or highly customized units may require 60-90 days. -
Q: How do I select the right number of effects?
A: The optimal number balances energy savings vs. capital cost. For most API applications, 3-5 effects provide a good return. Our engineers can perform a thermal analysis based on your actual process parameters. -
Q: Do you offer after-sales service for overseas customers?
A: Absolutely. We provide online technical support, spare parts supply, and if needed, on-site commissioning by our experienced engineers (travel expenses apply).
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