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Help CenterPharmaceutical Grade Tubular Three-Effect Evaporator for API Concentration and Solvent Recovery
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Welcome to Qingdao Conqinphi Environmental Technology Group Co., Ltd. – a leading manufacturer of high-performance evaporation systems since 2015. With a 10,000–30,000 m² factory and annual exports exceeding US$10 million, we proudly serve clients across North America, Europe, Asia, and more. Our Pharmaceutical Grade Tubular Three-Effect Evaporator is designed specifically for API concentration and solvent recovery, delivering superior efficiency, GMP compliance, and energy savings. This robust system meets the strictest pharmaceutical standards while reducing operating costs – a true game-changer for your production line.
This evaporator utilizes a three-effect structure to maximize heat utilization, dramatically lowering steam consumption compared to single-effect units. The tubular design ensures gentle handling of heat-sensitive APIs, preserving product quality. Whether you are optimizing existing processes or launching new drugs, our evaporator offers scalable capacity (from 500 L/h to 5,000 L/h) and customizable material selection (SS316L or higher). Backed by ISO9001 and HACCP certifications, every unit is factory-tested and validated for reliable long-term operation.
Key Features & Benefits
- Three-Effect Thermal Integration: Energy consumption reduced by up to 60% compared to single-effect systems – lower utility bills and smaller carbon footprint.
- Tubular Heat Exchanger Design: High heat transfer coefficient, minimal fouling, and easy CIP (Clean-in-Place) – less downtime and consistent performance.
- Pharmaceutical-Grade Finish: All product-contact surfaces are electropolished to Ra ≤ 0.4 μm, ensuring no contamination and full compliance with GMP and FDA guidelines.
- Intelligent Control System: PLC with HMI touchscreen enables precise temperature, pressure, and flow control – data logging and remote monitoring available.
- Solvent Recovery Efficiency: Condensation system achieves >95% solvent recovery – valuable for API purification and reducing raw material costs.
- Compact Modular Design: Pre-assembled skid-mounted unit reduces installation time – ideal for both new facilities and retrofit projects.
- Multi-Safety Protections: Over-pressure relief, vacuum break, emergency stop, and leak detection – safe operation even with volatile organic solvents.
- Wide Application Scope: Suitable for concentrating APIs like antibiotics, steroids, vitamins, and recovering ethanol, acetone, methanol, etc.
Technical Specifications
| Parameter | Standard Range | Notes |
|---|---|---|
| Evaporation Capacity | 500 – 5000 L/h | Customizable upon request |
| Number of Effects | 3 | Optional 4-effect available |
| Operating Temperature | First effect: 80–120°C; Final effect: 40–60°C | Adjustable per API requirement |
| Vacuum Range | -0.08 to -0.095 MPa | Maintained by vacuum pump |
| Heating Source | Steam (0.3–0.8 MPa) | Electric heating optional |
| Material of Construction | SS316L (1.4404) | Hastelloy C276 available |
| Control System | PLC + Touch Screen | SCADA integration optional |
| Installation Footprint | 6m × 3m × 4m (approx.) | Exact dimensions per capacity |
| Certification Compliance | ISO9001, HACCP, GMP | Other standards upon request |
Why Choose Conqinphi?
As an experienced manufacturer with a dedicated R&D team and over 200 skilled employees, we have delivered evaporation systems to pharmaceutical companies worldwide. Our evaporators are used for concentrating antibiotics, recovering solvents from fermentation broths, and processing sterile APIs. We provide complete documentation packages including IQ/OQ/PQ protocols, material certificates, and FAT reports. With our port in Qingdao, we ensure fast, safe global shipping.
Trust is built on results. In 2024 alone, our evaporators processed over 100,000 tons of pharmaceutical intermediates across 15 countries. Our after-sales team offers remote troubleshooting, spare parts supply, and on-site commissioning support. Whether you need a standard 1000 L/h unit or a custom 5000 L/h system, we invite you to contact us for a detailed proposal. Experience the Conqinphi difference – where quality meets efficiency.
Frequently Asked Questions
Q1: What APIs can your evaporator handle? Can it concentrate heat-sensitive compounds?
A: Yes. Our three-effect tubular design operates under vacuum at low temperatures (40–80°C in later effects), making it ideal for heat-sensitive APIs such as antibiotics, steroids, vitamins, and peptides. The gentle evaporation preserves product integrity.
Q2: How efficient is the solvent recovery? What solvents are compatible?
A: The recovery rate typically exceeds 95% for common solvents like ethanol, methanol, acetone, ethyl acetate, and isopropanol. We design the condenser and reflux system based on your specific solvent mixture to maximize yield.
Q3: Do you provide GMP compliance documentation? Can it pass FDA audits?
A: Absolutely. We supply comprehensive validation packages including DQ, IQ, OQ, PQ protocols, material traceability records, and welding logs. Our system is designed to meet FDA 21 CFR Part 11 (electronic records) and current GMP standards. Many of our clients have successfully passed regulatory inspections.
Q4: What is the typical lead time and shipping method?
A: Lead time depends on capacity and customization – standard units take 6–8 weeks. Custom designs require 10–12 weeks. We ship via sea freight from Qingdao Port, and can arrange air freight for smaller components if urgent.
Q5: How do you ensure easy cleaning and maintenance?
A: The tubular design includes CIP spray balls and drain ports for effective cleaning. All surfaces are electropolished to minimize adhesion. Maintenance access is provided via quick-open covers. We also offer an optional automated CIP skid.
Q6: Can the system be integrated with existing plant automation?
A: Yes. Our PLC supports common communication protocols (Modbus, Profibus, Ethernet/IP) for integration with DCS or SCADA. We can also provide OPC UA server interface upon request.
Q7: What warranty and after-sales support do you offer?
A: We provide a standard 1-year warranty covering manufacturing defects. Extended warranties are available. Our technical team offers remote support via video call, and we can dispatch engineers for on-site installation and training (travel expenses apply).
Q8: Can you provide references or case studies?
A: Certainly. We have references from established API manufacturers in Europe and Asia. We can share anonymized performance data and contact you with clients who have similar applications (subject to confidentiality agreements).
Ready to upgrade your API concentration process? Contact us today for a free technical consultation and customized quotation. Let Conqinphi be your trusted partner in pharmaceutical evaporation.
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