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Help CenterPharmaceutical Grade Crystallization Evaporator for API Purification, GMP Compliant, 304 Stainless Steel
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Qingdao Conqinphi Environmental Technology Group Co., Ltd. is proud to introduce our Pharmaceutical Grade Crystallization Evaporator, specifically engineered for API purification in demanding pharmaceutical environments. Manufactured from premium 304 stainless steel and fully compliant with GMP standards, this equipment ensures superior product purity, consistent crystal formation, and reliable operation. With over a decade of manufacturing expertise since 2015, our factory spanning 10,000–30,000 square meters and a dedicated team of 201–300 employees, we deliver solutions that meet the highest international quality benchmarks.
Key Features & Technical Specifications
- Premium Material Construction: All wetted parts are made of 304 stainless steel, offering excellent corrosion resistance and easy cleanability. Surface finish is mirror-polished (Ra ≤ 0.4μm) to prevent product adhesion and bacterial growth.
- GMP-Compliant Design: The evaporator is designed in accordance with Good Manufacturing Practice (GMP) guidelines, including smooth internal surfaces, no dead legs, and hygienic connections. All welds are fully passivated and documented.
- Optimized Crystallization Process: Advanced temperature and pressure control systems allow precise manipulation of supersaturation, ensuring uniform crystal size distribution and high purity of API crystals. The system supports both batch and continuous operation modes.
- High Efficiency & Energy Saving: Integrated heat recovery and multiple-effect evaporation options reduce energy consumption by up to 30% compared to traditional single-effect units. The evaporator achieves high concentration ratios while minimizing solvent losses.
- Intelligent Control System: Equipped with a PLC & HMI (optional) for automated monitoring of temperature, pressure, level, and flow rates. Real-time data logging and alarm functions enhance operational safety and traceability.
- Easy Maintenance & CIP/SIP: The modular design facilitates quick disassembly and cleaning. Supports Clean-in-Place (CIP) and Sterilize-in-Place (SIP) cycles, reducing downtime between batches.
Typical Technical Parameters (Customizable)
| Parameter | Specification |
| Material of Construction | 304 Stainless Steel (SS304) |
| Capacity Range | 50 – 10,000 L (customizable) |
| Operating Temperature | -20°C to 150°C (depending on media) |
| Operating Pressure | Vacuum to 0.5 MPa (customizable) |
| Surface Finish | Ra ≤ 0.4μm (mirror polish) |
| Control System | PLC + HMI (Siemens, Schneider, or custom) |
| Compliance | GMP, cGMP design principles |
Benefits for Your API Purification Process
- Superior Purity: The controlled crystallization environment minimizes impurities and ensures consistent crystal habit, meeting stringent pharmacopoeia standards.
- Scalability: From lab-scale R&D to full commercial production, our evaporators can be scaled with minimal process revalidation.
- Reduced Solvent Usage: The efficient evaporation and recovery system helps recycle solvents, lowering operational costs and environmental impact.
- Flexible Design: Options for jacket, internal coils, or external heat exchangers; multiple agitator types (anchor, turbine, etc.) available upon request.
- Global Service Support: With annual export value of US$10–50 million, we serve markets across North America, Europe, Asia, Africa, and Oceania, providing prompt after-sales service and spare parts delivery.
Why Choose Qingdao Conqinphi Environmental Technology Group? Since 2015, we have grown into a leading manufacturer with a 10,000–30,000 m² factory, employing over 200 skilled professionals. Our products are certified under multiple international standards including ISO9001, ISO14000, OHSAS18001, SA8000, and HACCP. We are committed to delivering reliable, compliant, and high-performance equipment to the pharmaceutical industry. Every unit undergoes rigorous testing and documentation before shipment from Qingdao Port.
Contact us today to discuss your specific API purification requirements. Our engineering team can customize the crystallization evaporator to match your process parameters, ensuring seamless integration into your existing production line. We look forward to partnering with you for your next critical project.
Frequently Asked Questions (FAQ)
Q1: Is this evaporator suitable for heat-sensitive APIs?
A: Yes, the precise temperature control and vacuum operation allow low-temperature evaporation and crystallization, preserving the integrity of heat-sensitive compounds.
Q2: Can the evaporator be used for both aqueous and organic solvent systems?
A: Absolutely. The 304 stainless steel construction is compatible with most common solvents (alcohols, ketones, esters, etc.). For highly corrosive media, we recommend optional 316L or Hastelloy materials.
Q3: What is the typical delivery time?
A: Lead time depends on the capacity and customization level. Standard units are typically shipped within 30–45 days after order confirmation. Custom designs may require 60–90 days.
Q4: Do you provide installation and commissioning services?
A: Yes, we offer on-site installation supervision and commissioning support. Remote technical assistance is also available via video call or phone.
Q5: How do you ensure GMP compliance of the equipment?
A: Our design follows GMP guidelines, including material certificates, surface finish reports, weld inspection records, and cleanability validation. We can provide a comprehensive documentation package upon request.
Q6: What is the warranty period?
A: We offer a standard 12-month warranty from the date of shipment, covering manufacturing defects. Extended warranty options are available.
Q7: Can you provide a pilot-scale unit for testing?
A: Yes, we have pilot-scale evaporators (10–50L) available for rent or purchase to validate your process before scaling up.
Q8: Is the equipment supplied with ATEX or other explosion-proof certifications?
A: Explosion-proof (ATEX/IECEx) versions are available as an option. Please specify the hazardous area classification when ordering.
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