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Abstract
Polydeoxyribonucleotide (PDRN) is a natural, DNA-derived therapeutic agent, typically extracted from salmon trout or chum salmon sperm, composed of deoxyribonucleotide polymers (50–1,500 kDa). It functions by activating adenosine A2A receptors and providing building blocks for tissue repair, promoting anti-inflammatory, angiogenic, and anti-aging effects. PDRN is widely used in regenerative medicine, dermatology (skin regeneration, hair loss), and for treating chronic wounds and musculoskeletal disorders.
Description
Composition: PDRN consists of a mixture of linear deoxyribonucleotide polymers, primarily extracted from salmon sperm cells.
Source: It is derived from Oncorhynchus mykiss (Salmon Trout) or Oncorhynchus keta (Chum Salmon) through a purified, sterilized process that removes active proteins and peptides.
Structure: It has a high structural similarity to human DNA (around 98%).
Characteristics: It is a colorless, water-soluble substance used in injectable forms, creams, and serums.
Function
Adenosine A2A Receptor Activation: PDRN binds to adenosine A2A receptors, stimulating cell growth, angiogenesis (new blood vessel formation), and anti-inflammatory pathways.
DNA Salvage Pathway: It provides nucleotides and nucleosides that enable the cell to repair damaged DNA and boost metabolic activity for cell rejuvenation.
Collagen Synthesis: It increases collagen production and fibroblasts, improving skin elasticity and structural integrity.
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