7,8-Dihydroxyflavone 38183-03-8

7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF).7,8-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier.7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome. 7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents. In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity. It was also found to block methamphetamine-induced dopaminergic neurotoxicity, an effect which, in contrast to the preceding, was found to be TrkB-dependent.Prodcut name:  7,8-DihydroxyflavoneSpecification:  98%Appearance: Yellow powderMesh size: 80 MeshCAS No.:  38183-03-8 Molecular formula: C15H10O4 Molecular weight: 254.238 g/mol Grade: Pharmaceuticals IngredientsBrand Name: LS-HerbTest Method: HPLCBiological DescriptionSelective TrkB receptor agonist. Flavonoid. Enhances synaptic plasticity in vivo and in vitro. Blood-brain barrier permeable.Useful References7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats.A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease.