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Welcome to Anping County Boli Hardware Wiremesh Products Factory – a trusted manufacturer with over 25 years of experience in filtration solutions. Our Skeleton-Supported Filter Cartridge for Pharmaceutical Industry (0.2μm Sterile Filtration) is engineered to meet the highest standards of purity and reliability in critical sterile applications. With an annual export value exceeding US$5 million and a global customer base spanning North America, Europe, Asia, and beyond, we bring unmatched expertise and quality control to every cartridge we produce.
This cartridge features a robust skeleton support structure that prevents collapse under high differential pressure, ensuring consistent 0.2 micron absolute filtration. Designed specifically for pharmaceutical sterile processes, it effectively removes bacteria, yeast, and other microorganisms while maintaining high flow rates and low pressure drop. Our commitment to precision manufacturing and rigorous testing means you can rely on this cartridge for critical applications such as buffer filtration, media sterilization, and final product filling.
Key Features & Technical Specifications
| Filtration Media | Hydrophobic or hydrophilic PTFE membrane / PES membrane |
| Support Structure | Stainless steel or polypropylene skeleton (optional) |
| Filtration Area | 0.5 – 2.5 m² per 10-inch cartridge |
| Maximum Operating Pressure | 4.0 bar at 25°C |
| Maximum Operating Temperature | 80°C (continuous), higher options available |
| Bacterial Retention | LRV ≥ 7 for Brevundimonas diminuta (0.2μm) |
| Sterilization | Autoclavable at 135°C, or in-line steam sterilization |
Product Advantages
- Superior Mechanical Strength: The skeleton support prevents deformation even under high flow or pressure surges, ensuring long service life and consistent filtration performance.
- High Purity & Low Extractables: Manufactured from FDA-compliant raw materials, our cartridges minimize leachables and particulates, protecting sensitive pharmaceutical formulations.
- Optimized Flow Design: Pleated filter media with high surface area delivers high flow rates while maintaining low pressure drop, improving overall process efficiency.
- Validated Sterile Performance: Each cartridge is integrity-tested using bubble point or diffusion methods to guarantee 0.2μm absolute retention.
- Customizable Configurations: Available in multiple lengths (10 to 40 inches), end cap styles (226, 222, flat, etc.), and seal materials to fit standard housings.
- Global Regulatory Compliance: Designed to meet USP Class VI, FDA 21 CFR 177, and EU Pharmacopoeia requirements for pharmaceutical use.
Applications in Pharmaceutical Industry
- Sterile filtration of buffers, media, and additives
- Final fill filtration for injectable drugs and ophthalmic solutions
- Bioburden reduction in intermediates and bulk products
- Prefiltration for sensitive downstream processes
- Air and gas venting with hydrophobic membranes
Why Choose Boli Skeleton-Supported Filter Cartridge?
Our cartridge stands out due to its rugged construction and unmatched reliability. The skeleton support system not only enhances mechanical stability but also allows for a more compact design, making it ideal for retrofitting into existing filtration systems. Additionally, the use of advanced membrane technology ensures consistent retention of microorganisms, reducing the risk of contamination and batch failure.
Frequently Asked Questions (FAQ)
-
What is the difference between skeleton-supported and standard pleated filter cartridges?
Skeleton-supported cartridges have an internal rigid support structure (e.g., stainless steel or polypropylene) that reinforces the filter media. This prevents collapse under high differential pressure, extending cartridge life and maintaining filtration integrity compared to standard cartridges without support. -
Can this cartridge be used for both liquid and gas filtration?
Yes, depending on the membrane choice. Hydrophilic membranes are suitable for aqueous liquids, while hydrophobic membranes are designed for gas venting and air filtration. Please specify your application when ordering. -
Is the cartridge compatible with common pharmaceutical housings?
Absolutely. Our cartridges are available with standard end cap configurations (226, 222, flat, etc.) and seal materials (silicone, EPDM, Viton) to fit most industry-standard housings. Custom adapters can also be provided. -
How do you validate the 0.2μm sterile filtration performance?
Each batch is tested using a non-destructive bubble point test correlated with bacterial retention tests (LRV ≥ 7 for Brevundimonas diminuta). A certificate of conformance is provided with each shipment. -
What is the typical shelf life of this cartridge?
When stored in a cool, dry place away from direct sunlight, the shelf life is up to 3 years from the date of manufacture. The packaging is designed to maintain cleanliness. -
Can you provide custom lengths or diameters?
Yes, we offer customization for length, diameter, end cap, and seal material to meet specific requirements. Minimum order quantities may apply for non-standard sizes. Please contact our sales team for details. -
Does the cartridge require any pre-conditioning before use?
For optimal performance, we recommend flushing the cartridge with sterile water or the process fluid to remove any residual air and to wet the membrane. Refer to the product manual for detailed instructions.
Trust & Reliability from a Global Manufacturer
Since 1998, Anping County Boli Hardware Wiremesh Products Factory has been a reliable partner for filtration solutions worldwide. With annual exports of US$5–10 million and a presence in over 15 markets including North America, Europe, Southeast Asia, and the Middle East, we have earned the trust of pharmaceutical companies, biotech firms, and research institutions. Our state-of-the-art production facility in Hengshui, Hebei, China, is equipped with advanced testing equipment to ensure every cartridge meets strict quality standards.
We offer flexible shipping options from major ports including Tianjin, Qingdao, Shanghai, and Foshan, ensuring timely delivery to your location. Our dedicated after-sales support team provides technical guidance and troubleshooting assistance. Whether you require a single cartridge for validation or bulk orders for full-scale production, we are committed to delivering excellence.
Contact us today to request a quote or sample. Let Boli be your partner in sterile filtration excellence.
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