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PE/PA Membrane Filter Cartridge 0.22 Micron 10 Inch for Sterile Filtration in Biotech Manufacturing
Product Spotlights
PE/PA 0.22 micron absolute filter cartridge with dual-layer depth filtration, high flow rate, and low protein binding. Compatible with steam sterilization and integrity testing. Ideal for sterile filtration of biotech fluids, buffers, and water. Available in 10-inch length with customizable end caps. Trusted manufacturer since 1998, global exporter.
Negotiable
MOQ: 1 Piece (Price negotiable depending on order volume and customization)
Key Specifications
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Material:
PE/PA (polyethylene/polyamide)
Pore Size:
0.22 micron
Length:
10 inch (250 mm)
Payment & Shipping
Payment Methods:
Port of Shipment:
tianjin shanghai qingdao
Delivery Detail:
Delivery time depends on order quantity.
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Material
PE/PA (polyethylene/polyamide)
Pore Size
0.22 micron
Length
10 inch (250 mm)
Application
Sterile filtration in biotech manufacturing
Filtration Type
Membrane depth filter
Maximum Operating Temperature
80°C (176°F)
Maximum Differential Pressure
0.4 MPa at 25°C
Cartridge Diameter
2.5 inch (standard 222/226 O-ring)
End Cap Configuration
Double open end (DOE) or 222/226 fin
As a leading manufacturer since 1998, Anping County Boli Hardware Wiremesh Products Factory is proud to present our PE/PA Membrane Filter Cartridge – a precision-engineered solution for sterile filtration in biotech manufacturing. With an annual export value of US$5-10 million and a global presence across North America, Europe, Asia, and beyond, we combine decades of filtration expertise with rigorous quality control. This 0.22 micron, 10-inch cartridge is designed to deliver absolute bacteria retention, high flow rates, and consistent performance, making it an ideal choice for critical applications such as pharmaceutical water, buffer solutions, and fermentation media.
Key Features & Specifications
- Dual-Layer Membrane Structure: PE (polyethylene) pre-filter layer combined with PA (polyamide) final membrane ensures high dirt-holding capacity and reliable 0.22 micron absolute filtration.
- High Flow & Low Pressure Drop: Optimized pleat design maximizes effective filtration area, reducing energy consumption and extending service life.
- Chemical Compatibility: Resistant to a wide range of solvents, acids, and alkalis (pH 2-12), suitable for aggressive biotech processes.
- Thermal Stability: Can withstand repeated autoclave sterilization (121°C) or in-line steam sterilization (134°C) without degradation.
- Low Extractables: Manufactured with pure materials and no binders, meeting USP <87> and USP <88> cytotoxicity standards (test results available upon request).
- Multiple End Configurations: Available with 222/226 O-ring, flat gasket, or DOE (double open end) to fit standard housings.
| Parameter | Value |
|---|---|
| Pore Size | 0.22 μm (absolute) |
| Length | 10 inch (250 mm) |
| Outer Diameter | 2.5 inch (63 mm) |
| Recommended Flow Rate | Up to 0.5 L/min per 10-inch cartridge (for water) |
| Maximum Operating Temperature | 80°C (continuous); 134°C (steam, 30 min) |
| Maximum Differential Pressure | 0.4 MPa at 25°C; 0.2 MPa at 80°C |
| Bacteria Retention | LRV > 7 for Brevundimonas diminuta (ASTM F838) |
Advantages for Biotech Manufacturing
- Sterile Assurance: Validated to achieve a sterility assurance level (SAL) of 10⁻⁶, critical for injectables and cell culture media.
- Low Protein Binding: Hydrophilic PA membrane minimizes protein adsorption, preserving product yield in bioprocessing.
- Integrity Testable: Compatible with bubble point and diffusion tests, enabling in-process filter integrity verification.
- Scale-Up Flexibility: Available in 10-inch, 20-inch, 30-inch, and 40-inch lengths, plus multiple cartridges per housing for production scaling.
- Cost-Effective: High dirt-holding capacity reduces replacement frequency, lowering total cost of ownership.
Trusted by Global Partners
With over 25 years of manufacturing experience, Anping Boli exports to more than 20 countries and regions, including North America, Europe, Southeast Asia, and the Middle East. Our factory is equipped with advanced pleating and welding machines, and each cartridge undergoes 100% integrity testing before shipment. We offer customizable options (end cap type, gasket material, special packaging) and provide technical support for filter validation. Our annual export value of US$5-10 million reflects the trust of global biotech manufacturers. We invite you to contact us for samples, specifications, or a quotation – let our quality speak for itself.
Frequently Asked Questions
-
Q: Can this cartridge be used for sterilizing gases?
A: Yes, the 0.22 micron rating is suitable for sterile gas filtration (e.g., air, nitrogen). However, for absolute sterility in gases, we recommend a hydrophilic filter with a downstream vent. -
Q: How do I sterilize the filter before use?
A: The cartridge can be autoclaved at 121°C for 30 minutes or steam sterilized in-line at 134°C for 20 minutes. Ensure the housing is compatible. -
Q: What is the typical lifespan of this cartridge?
A: Lifespan depends on feed water quality and operating conditions. In typical biotech water systems, a 10-inch cartridge can last 2-4 weeks before replacement. We recommend monitoring differential pressure. -
Q: Does this cartridge contain any adhesives or binders?
A: No, the PE/PA membrane is thermally bonded without adhesives, minimizing extractables and ensuring purity. -
Q: Is the cartridge compatible with 10% sodium hypochlorite for cleaning?
A: Yes, short-term exposure (up to 30 minutes) to 10% NaOCl is acceptable for chemical cleaning. Always rinse thoroughly with WFI after cleaning. -
Q: Can I request a filter validation guide?
A: Absolutely. We provide validation documents including bacterial retention, extractables, and integrity test protocols upon request. -
Q: What gasket materials are available?
A: Standard materials are silicone, EPDM, and Viton. Custom options are available for special chemical compatibility. -
Q: How do I ensure the correct end cap for my housing?
A: Please provide your housing model or the type of O-ring/gasket seat. Our technical team can recommend the appropriate configuration (222, 226, flat gasket, or DOE).
Send Inquiry to This Supplier
Mr. Geng Xiaozhong
Sales Manager
2Yrs
Hengshui, Hebei, China
2Yrs
Business Type
Manufacturer
Year Established
1998
Annual Export Value
US$5 Million - US$10 Million
Port of Shipment
Tianjin, Qingdao, qingdao, shanghai, foshan
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