Natural 95% Caryophyllene Oxide CAS No 1139-30-6

 
What is Caryophyllene Oxide? 
Caryophyllene oxide is a sesquiterpene that results from the oxidation of β-caryophyllene, which can occur during the harvest's cure. It is also considered non-toxic, and non-sensitizing, and has been indicated as an anticoagulant with platelets.

Caryophyllene oxide is present in plants' profiles like eucalyptus, lemon balm, oregano, wormwood, rosemary, guava, black pepper, and clove. It has been used in cosmetics, drugs, food preservatives, and for training drug-sniffing dogs by law enforcement.  

This terpene interacts with the endocannabinoid system by binding directly with CB2 receptors. Like other terpenes, its benefits include anticancer, anti-inflammatory, analgesic, and anti-bacterial properties. It has been compared to ciclopirox olamine and sulconazole as an antifungal, mainly used in toenail fungus treatment and other skin and nail fungi.

Caryophyllene Oxide Function:

Many terpenes have similar benefits.   However, we are in the infancy stages of understanding their full potential and their interactions.    Caryophyllene Oxide has been identified to be beneficial as:
1. Anticoagulant
A recent study suggests that isolated Caryophyllene oxide showed significant anti-platelet aggregation activity, indicating it could potentially prevent coagulation of the blood (Yang, Millet-Clerc, Chaumont, & Michel, 1999).
2. Anticancer
Like many other terpenes, Caryophyllene can help potentiate anti-cancer drug efficacy. For example, it can enhance the chemotherapy drug doxorubicin in the treatment of intestinal cancer cells.   Besides, combined with doxorubicin and paclitaxel shows anticancer activities in human leukemia, multiple myeloma, and human prostate cancer cell lines.   In general, Caryophyllene has "equally strong (or even stronger) anticancer activity than [β-caryophyllene]." Further research is needed to determine if it prevents cell proliferation and induces apoptosis.   ( Sain, S., 2014)
3. Antifungal
Caryophyllene Oxide is also known for its antifungal properties.   When tested on nail and skin fungi, the terpene's antifungal activity is comparable to fungal treatment drugs, such as ciclopirox olamine and sulconazole (yang, Millet-Clerc, Chaumont, & Michel, 1999).
4. Anti-Inflammatory
Another benefit of Caryophyllene Oxide is its analgesic and anti-inflammatory properties. Caryophyllene oxide combined with unsaponified petroleum ether extract showed significant central and peripheral analgesic, along with anti-inflammatory activity. These activities of caryophyllene oxide were comparable with the standard drug used in the respective experiments(Javed, Azimullah, Haque, & Ojha, 2016).


Caryophyllene Oxide Application:

1. Used in the manufacturing of lavender fragrances;
2. Used in all food and beverage flavors;
3. Used in the pharmaceutical industry, such as used as an effective antifungal, anesthetic, antioxidant, and anticoagulant with platelets.

Packaging:
Solid Packaging:  Customary Packing: 1kg/10kg/25kg (can pack according to customer's request).
Liquid Packaging:  Customary Packing:125ml, 500ml, 1Liter,5Liter (can pack according to customers' request).

Shipping:   Shipping by express, air, Sea, and some special line to most Countries.
Normally for small quantities, we will ship them by DHL, FedEx, UPS, special line, and so on, for big quantities By Air, Sea, and some special line to most countries.

Shaanxi Hongkang Biological Technology Co., Ltd was founded in September 2003 with a registered capital of 5 million. Consists of Flavors and cooling agent(Koolada) R&D centers, a QC& QA center, an Administrative Center, and A High-Performing Sales Team. Specializing in the research and development, production, and sales of flavors and fragrances.

Our company's main products include the Cooling agent series (WS-23, WS-10, WS-12, WS-3, WS-5), L-Menthyl lactate, L-Monomenthyl glutarate, Peppermint oil, Butyl Butyral Lactate(N), Butter esters, Caryophyllene Oxide, Menthyl PCA, 2,4-Decadienal, Vanillin isobutyrate, Maltol isobutyrate, Megastinmatrienone, Sandenol 803, Dihydroactinidiolide, Zingerone, 5-Methyl-2-phenyl-2-hexenal, Vanillin butyl ether, Ethyl 2-methyl butynate, plant aroma/fragrance essential oils, synthetic flavors and natural flavors. The company′ S products can be used in food and beverage, daily chemical, medicine, and other industries, with a wide range of downstream application fields and development space.

We specialize in the manufacture of Cooling Agents, mixed unflavored liquid essential oil, Since its inception, the company has aimed at providing every customer with top-quality products and superior service at a reasonable and competitive price, all the time. And in the past 10 years, we've gained great progress.

Products are exported all over the world: USA, countries in North America, South America, European countries like the UK, Germany, Sweden, Greece, Finland, Norway, France, Italy, Russia, Ukraine, Estonia, Spain, Latvia, etc. Asia countries like Malaysia, Indonesia, South Korea, Thailand, Philippines, Vietnam, Singapore, etc. Our products are selling very well in these areas. And other countries like Australia, Mexico, Salvatore, Costa Rica, and so on. What's more, for the high-quality products and superior service we provide, we've been highly appreciated by our customers.

Shaanxi Hongkang will continue to focus on and serve human health from a global perspective. and create high-quality products in the field of green health. Providing users with satisfactory products is our constant pursuit. 

Q1: Could you provide free samples for testing?
A1: Yes, we can provide free testing, and shipping costs are paid by our customers.

Q2: Which payment terms do you accept?
A2: online order, PayPal, West Union, T/T, etc.

Q3: What about the MOQ?
A3: The MOQ of each flavor is 125ml, but the first weight of the shipping fee is 1L, we recommend you buy 1L or 125ml*8, which will be more economical.

Q4: What's the delivery time?
A4: The goods will be sent out about 3 days after receiving the payment, the delivery time is about 6-15 days.

Q5: What about the Shipping method?
A5: Door to Door by FedEx, TNT, UPS, DHL, Dedicated Line, etc.

Q6: Which country can you ship to?
A6: We can ship to almost every country all over the world, and we have a stable shipping method. If you have a forwarder agent in China, we can also send the goods to your shipping agent freely.

Q7: How to order?
Leave us a message, we'll send you our product list price lists for your reference.