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Help CenterFactory Supply 99.5% High Purity Alpha-Arbutin 84380-01-8
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Alpha-Arbutin
Synonyms:4-hydroquinone-alpha-d-glucopyranoside;alpha-arbutin;a-Arbutin;HydroquinoneO-α-D-Glucopyranoside;
4-Hydroxyphenyla-D-glucopyranoside;4-hydroxyphenylalpha-D-glucopyranoside
CAS:84380-01-8
MF: C12H16O7
MW:272.25
EINECS: 209-795-0
Appearance: White crystalline powder
Content (HPLC): ≥ 99.5%
Loss on drying:
PH value (10% aqueous solution): 5.0~7.0
Melting point (℃): 202-210
Burning residue: ＜ 0.5%
Transmittance (430nm) (5% aqueous solution): ＞ 95
Hydroquinone (ppm): ＜ 10
Arsenic (ppm): ＜ 2
Heavy metal (ppm): ＜ 10
Total bacterial count (CFU/g): ≤ 1000
Mold and yeast (CFU/g): ≤ 100
Pseudomonas aeruginosa (CFU/g): Not detectable
Staphylococcus aureus (CFU/g): not detectable
Thermotolerant coliform group (CFU/g): not detectable
Uses: α-Arbutin may be used as an analytical reference standard for the determination of the analyte in cosmetics
by high-performance liquid chromatography with UV detection (HPLC-UV) method.
Biological Functions: Alpha arbutin acts as a tyrosinase competitive inhibitor and also slows melanosome
maturation (the organelles that synthesize and store melanin or pigment).3 This is significant because it
works on two different mechanisms of pigmentation. Melanin is derived from the amino acid tyrosine and
this conversion is regulated by the enzyme tyrosinase. Alpha arbutin is similar in structure to tyrosine,
which fits into tyrosinase, needed for melanogenesis. This means that alpha arbutin is reversibly competing
with tyrosine for a spot on the enzyme and not inhibiting cell viability, so therefore is not cytotoxic.
By targeting tyrosinase, the rate-limiting enzyme in melanin formation, as well as slowing production of the
organelles that produce melanin, alpha arbutin is a potent skin brightening agent.
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