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The Brief Introduction to Fisetin
Product Name: Fisetin
CAS NO.: 528-48-3
Molecular Formula: C15H10O6
Molecular Weight: 286.23
Purity: The assay of Fisetin provided by Xi’an KinGreen CO.,Ltd. is 10%-- 98%
Appearance: Yellowish-brown fine powder
Test Method: HPLC
Product—Brand: Xi’an KinGreen
Pharmacological effects:
Fisetin, a natural flavonol present in edible vegetables, fruits, and wine, was reported to exert anticarcinogenic effects. The objective of the current study was to examine the effect of fisetin on the cell cycle progression of the human colon cancer cell line HT-29. HT-29 cells were cultured in serum-free medium with 0, 20, 40, or 60 µmol/L fisetin. Fisetin dose dependently inhibited both cell growth and DNA synthesis (P < 0.05), with a 79 ± 1% decrease in cell number observed 72 h after the addition of 60 µmol/L fisetin. Perturbed cell cycle progression from the G1 to S phase was observed at 8 h with 60 µmol/L fisetin treatment, whereas a G2/M phase arrest was observed after 24 h (P < 0.05). The phosphorylation state of the retinoblastoma proteins shifted from hyperphosphorylated to hypophosphorylated in cells treated with 40 µmol/L fisetin. (P < 0.05). Fisetin decreased the activities of cyclin-dependent kinases (CDK)2 and CDK4; these effects were likely attributable to decreases in the levels of cyclin E and D1 and an increase in p21CIP1/WAF1 levels (P < 0.05). However, fisetin also inhibited CDk4 activity in a cell-free system (P < 0.05), indicating that it may directly inhibit CDk4 activity. The protein levels of cell division cycles (CDC)2 and CDC25C and the activity of CDC2 were also decreased in fisetin-treated cells (P < 0.05). These results indicate that inhibition of cell cycle progression in HT-29 cells after treatment with fisetin can be explained, at least in part, by modification of CDK activities.
Supplier: Xi’an KinGreen Bio-Engineering Technology Co., Ltd.
Storage: Store in cool & dry place, Keep away from strong light and heat.
Shelf life: 2 years
Package: 1kg/ aluminum bag, 25kg in one barrel with two-double aluminum foil plastic bags inside. or according to the specific requirements of customers.
Advantages of Xi’an KinGreen Bio-Engineering Technology Co., Ltd.:
1. Our factory has been certifited by the ISO9001, Kosher, HACCP and Chinese GMP
2. We inspect the manufacture process and quality strictly
3. We supply reasonable price&prompt delivery
4. we build our specialized raw materials base according to GAP
5. 100% Natural porduct, without any synthetize ingredient.
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