Contact Platform Support
Help CenterNatural Colchicine 98%
Related Products
The Brief Introduction to Colchicine
Product Name: Colchicine
CAS NO.: 71963-77-4
Molecular Formula: C22H25NO6
Molecular Weight: 399.44
Purity: The assay of Colchicine provided by Xi’an KinGreen CO.,Ltd. is 98%
Appearance: White crystalline powder
Test Method: HPLC
Product—Brand: Xi’an KinGreen
Pharmacological effects:
Colchicine is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, Colchicum autumnale, also known as the "Meadow saffron"). Originally used to treat rheumatic complaints and especially gout, it was also prescribed for its cathartic and emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition. In neurons, axoplasmic transport is disrupted by colchicine
Biological function:Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. Availability of tubulin is essential to mitosis, and therefore colchicine effectively functions as a "mitotic poison" or spindle poison. Since one of the defining characteristics of cancer cells is a significantly increased rate of mitosis, this means that cancer cells are significantly more vulnerable to colchicine poisoning than are normal cells. However, the therapeutic value of colchicine against cancer is (as is typical with chemotherapy agents) limited by its toxicity against normal cells.Apart from inhibiting mitosis, a process heavily dependent on cytoskeletal changes, colchicine also inhibits neutrophil motility and activity, leading to a net anti-inflammatory effect. Colchicine also inhibits uric acid (urate) crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. The inhibition of uric acid crystals is a vital aspect on the mechanism of gout treatment.
Supplier: Xi’an KinGreen Bio-Engineering Technology Co., Ltd.
Storage: Store in cool & dry place, Keep away from strong light and heat.
Shelf life: 2 years
Package: 1kg/ aluminum bag, 25kg in one barrel with two-double aluminum foil plastic bags inside. or according to the specific requirements of customers.
Advantages of Xi’an KinGreen Bio-Engineering Technology Co., Ltd.:
1. Our factory has been certifited by the ISO9001, Kosher, HACCP and Chinese GMP
2. We inspect the manufacture process and quality strictly
3. We supply reasonable price&prompt delivery
4. we build our specialized raw materials base according to GAP
5. 100% Natural porduct, without any synthetize ingredient.
Send Inquiry to This Supplier
You May Also Like
-
Silymarin Milk Thistle Extract FactoryNegotiableMOQ: 1 Metric Ton -
CHINA Factory Distiller Small Extractor Steam Essential Oil Distillation Machine Essential Oil Making MachineNegotiableMOQ: 1
-
Cumin Seed PowderUS$ 4.79 - 4.79MOQ: 100 Kilograms
-
Portable Grouted Splice CouplerNegotiableMOQ: 1
-
New Tight-fitting Sportswear the Diving Suit Digital Print CustomNegotiableMOQ: 1
-
Sell Soybean IsoflavonesNegotiableMOQ: 1
-
Fuzz Cashmere Comb For Cashmere Sweaters With High QualityUS$ 0.6 - 0.8MOQ: 5000 Pieces
-
Garlic Oil, Garlic Seed Oil, Pure Garlic Oil AllicinUS$ 4.5 - 5.5MOQ: 1000 Kilograms
-
High Quality Hot Sell Senna PowderNegotiableMOQ: 200 Kilograms
-
Portulaca Oleracea ExtractNegotiableMOQ: 1 Kilogram
