Camptotheca Acuminata Extract Camptothecin of 98%

Specifications

Specification: 92%, 95%, 98%, 99% HPLC
Appearance: Light yellow crystal powder
Source: Camptotheca Acuminata Decne's leaf

 

                                                           

            Camptotheca Acuminata Extract Camptothecin of 98%

 

 

Camptothecin (CPT) is a cytotoxic quinoline alkaloid which inhibits the DNA enzymetopoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematicscreening of natural products for anticancer drugs. It was isolated from the bark and stem ofCamptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancertreatment in Traditional Chinese Medicine.                                                                  

                                                       

 

Product name:Camptothecin Extract             

Molecular formula: C20H16N2O4

Molecular weight: 348.36                      

Test method:HPLC

Appearance:Light yellow crystal powder

Source:Camptotheca Acuminata Decne's leaf    

Grade:Pharmaceutical and food

Storage: In clean, cool and dry

 

 

Specification:

 

92%, 95%, 98%, 99% HPLC

 

 

Function and usage:

 

1.Natural camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.

 

2.In clinical camptothecin is widely believed that natural camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, camptothecin is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, camptothecin ultimately causes cell death.

 

3.Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.

 

4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

 

 

Application:

 

1. Camptothecin can make changes in skin epidermal keratinization process.

 

2. Camptothecin is used for anti-cancer, anti-virus, immune inhibition, anti early pregnancy.

 

3. Camptothecin has the function of treatment of gastric cancer, liver cancer, head and neck cancer and leukemia, with fewer side effects than camptothecine.