Green coffee bean extract powder Chlorogenic acids

       Green coffee bean extract powder Chlorogenic acids

Specifications:

Molecular formula: C16H18O9
Molecular weight: 354.31
CAS No.: 327-97-9
Melting point:205-209°C
Solubility: Good solubility in water
Appearance: Fine crystal powder
Color: White
Specific Rotation : -36° (c=1, H2O) 
 

Functions and applications: 

1 The protection to cardiovascular

 A large number of experiments have show that Chlorogenic acid, as a kind of free radical scavenger and antioxidant, has a good protection to cardiovascular. Chang Cuiqing proved that chlorogenic acid has a preparatory prevention to the damage of endothelial cells induced by ox-LDL. Chlopcikova discovered that chlorogenic can protect Myocardium cell from being damaged by oxidant of Doxombiein,DOx and has a prominent inhibition of peroxidization of mitochondria envelope lipid induced by iron reserves dependence DOX. It goes to show chlorogenic acid can protect vascular endothelium cell by removing radical intermediate and antioxidant lipids and has a further prevention to arteriosclerosishypertension and thrombosis.

2 Anti-mutagens and anti-cancer

 The experiment of animals shows that chlorogenic acid can prevent and inhibit colon cancer and stomach cancer. Jiang discovered chlorogenic acid brought bigger DNA fragments produced by tumor cells and its agglutination. Aryl hydrocarbon hydroxylase is an important Metabolizing Enzyme of polynuclear aromatic and its activeness would improve the mutagens of anti- polynuclear aromatic of tissue cells. Research in vitro discovered that chlorogenic acid can improve the activeness of Aryl hydrocarbon hydroxylase. It also can inhibit the formation of 8-OHdG and the grow of Escherichia foetidaStaphylococcus aureusblack hay bacillus and legionella.

3 Reduce blood fat

 Veins have given chlorogenic the power of reducing cholesterol and triglycerides in the blood of rats. When adding chlorogenic acid to the food of rats, it discovered that the cholesterol in rats lungs and livers has also reduced.

4 Anti-leukemia

 Chiang found that chlorogenic acid had light activeness of anti-leukemia by the experiment in vitro. J. Bandyopadhyay has proved that chlorogenic acid can inhibit Ber-Abl and c-Abl and induce the dead of the original lymphocytosis in the body of leukemia patients.

5 Adjust the immune function

 The research in vitro has showed chlorogenic acid can obviously strengthen T cells caused by influenza as well as induce humans lymphocytes and albumen cells to produce 7-IFN and α-IFN. It can improve the lgG1 and Ll4 level of rats. In a recent research, it is discovered that chlorogenic acid has the ability to activate nerve cardiac troponin to strengthen the function of macrophages.

6 Lower glucose

 It is proved by the research of Andrade-Cetto and Wiedenfeld H thatChlorogenic acid has potential function in lowering glucose in animals body. The function may have relationships with the inhibiting of glucose-6- and the absorption of glucose.

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