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Specifications
Broom(Genista) Extract:Appearance:Light Yellow powder
Specification:Genistein(98%)
Isoflavones genistein and daidzein bind to and transactivate all three PPAR isoforms, and γ. For example, membrane-bound PPARγ-binding assay showed that genistein can directly interact with the PPARγ ligand binding domain and has a measurable Ki of 5.7 mM,Gene reporter assays showed that genistein at concentrations between 1 and 100 uM activated PPARs in a dose dependent way in KS483 mesenchymal progenitor cells, breast cancer MCF-7 cells, T47D cells and MDA-MD-231 cells, murine macrophage-like RAW 264.7 cells, endothelial cells and in Hela cells. Several studies have shown that both ERs and PPARs influenced each other and therefore induce differential effects in a dose-dependent way. The final biological effects of genistein are determined by the balance among these pleiotrophic actions. Tyrosine kinase inhibitor
The main known activity of genistein is tyrosine kinase inhibitor, mostly of epidermal growth factor receptor EGFR. Tyrosine kinases are less widespread than their ser/thr counterparts but implicated in almost all cell growth and proliferation signal cascades.
[edit] Redox-active - not only antioxidant
Genistein may act as direct antioxidant, similar to many other isoflavones, may alleviate damaging effects of free radicals in tissues.
The same molecule of genistein, similar to many other isoflavones, by generation of free radicals poison topoisomerase II, enzyme important for maintaining DNA stability.Human cells turn on beneficial, detoxyfying Nrf2 factor in response to genistein insult. This pathway may be responsible for observed health maintaining properities of small doses of genistein.[edit] Anthelmintic
The root-tuber peel extract of the leguminous plant Felmingia vestita is the traditional anthelmitic of the Khasi tribes of India. While investigating its anthelmintic activity, genistein was found to be the major isoflavone responsible for the deworming property.Genistein was subsequently demonstrated to be highly effective against intestinal parasites such as the poultry cestode Raillietina echinobothrida.the pork trematode Fasciolopsis buski,and the sheep liver fluke Fasciola hepatica. It exerts its anthelmintic activity by inhibiting the enzymes of glycolysis and glycogenolysis,and disturbing the Ca2+ homeostasis and NO activity in the parasites.It has also been investigated in human tapeworms such as Echinococcus multilocularis and E. granulosus metacestodes that genistein and its derivatives, Rm6423 and Rm6426, are potent cestocides
Atherosclerosis
Genistein protects against pro-inflammatory factor-induced vascular endothelial barrier dysfunction and inhibits leukocyte-endothelium interaction, thereby modulating vascular inflammation, a major event in the pathogenesis of atherosclerosis.Cancer links
Genistein and other isoflavones have been found to have antiangiogenic effects (blocking formation of new blood vessels), and may block the uncontrolled cell growth associated with cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors). Various studies have found moderate doses of genistein to have inhibitory effects on cancers of the prostate,cervical,brain,breast,and colon.Additionally it has been shown that genistein makes some cells more sensitive to radio-therapy; although, timing of phytoestrogen use is also important.
Genistein's chief method of activity is as a tyrosine kinase inhibitor. Tyrosine kinases are less widespread than their ser/thr counterparts but implicated in almost all cell growth and proliferation signal cascades. Inhibition of DNA topoisomerase II also plays an important role in the cytotoxic activity of genistei.Genistein has been used to selectively target pre B-cells via conjugation with an anti-CD19 antibody
Studies on rodents have found genistein to be useful in treatment leukemia and that it can be used in combination with certain other antileukemic drugs to improve their efficacy.
[edit] Estrogen receptor - more cancer links
Due to its structure similarity to 17β-estradiol (estrogen), genistein can compete with it and bind to estrogen receptors. However, genistein shows much higher affinity toward estrogen receptor β than toward estrogen receptor α.
Data from in vitro and in vivo research confirms that genistein can increase rate of growth of some ER expressing breast cancers. Genistein was found to increase the rate of proliferation of estrogen-dependent breast cancer when not cotreated with an estrogen antagonist.It was also found to decrease efficiency of tamoxifen and letrozole - drugs commonly used in breast cancer therapy.Genistein was found to inhibit immune response towards cancer cells allowing their survival.
[edit] Effects in males
Isoflavones can act like estrogen, stimulating development and maintenance of female characteristics, or they can block cells from using cousins of estrogen. In vitro studies have shown genistein to induce apoptosis of testicular cells at certain levels, thus raising concerns about effects it could have on male fertility;however, a recent study found that isoflavones had "no observable effect on endocrine measurements, testicular volume or semen parameters over the study period." in healthy males given isoflavone supplements daily over a 2 month period.Sanfilippo syndrome treatment
The group of Grzegorz Wegrzyn, from the Department of Molecular Biology of University of Gdansk, Poland, found that genistein decreases pathological cumulation of glycosaminoglycans in Sanfilippo syndrome. In vitro, animal studies and clinical experiments suggest that the symptoms of the disease may be alleviated by adequate dose of genistein.Genistein was found to also possess toxic properties toward brain cells.As one of the pathways stimulated by genistein is autophagy it may explain the observed efficiency of the substance, as autophagy is significantly impaired in the disease.Anyway, other autophagy stimulating substances are already known, having no toxic/mutagenic -topoisomerase inhibitory or hormonal properties.
1kg/bag, 5kg/bag, 25kg/drum, double layers plastic bags inside.
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
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