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Catharanthus Roseus Periwinkle Extract Vinblastine

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Negotiable MOQ: 1 Kilogram (Price negotiable depending on order volume and customization)
Key Specifications
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Type:
Herbal Extract
Variety:
Other, Periwinkle
Form:
Powder
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Ningbo Tianhong Biotech Co., Ltd.
Payment & Shipping
Payment Methods:
Port of Shipment:
Ningbo/Shanghai
Delivery Detail:
Delivery time depends on order quantity.

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Type Herbal Extract
Variety Other, Periwinkle
Form Powder
Part Other, stem,leaf,root,flower
Extraction Type Liquid-Solid Extraction
Packaging Drum, Vacuum Packed
Place of Origin Zhejiang, China
Grade Pharmaceutical Grade
Brand Name Tian hong
Model Number PWE

Specifications

Catharanthus Roseus Extract:
Appearance:White Powder
Specification:Vinblastine(98%)

Catharanthus Roseus Extract:
Indications and Usage
Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).

Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules.

 

Microtubule disruptive drugs like vinblastine, colcemid, nocodazole have been reported to act by two mechanisms. At very low concentrations they suppress microtubule dynamics and at higher concentrations they reduce microtubule polymer mass. Recent findings indicate that they also produce microtubule fragments by stimulating microtubule minus-end detachment from their organizing centers. Dose-response studies further indicate that enhanced microtubule detachment from spindle poles correlate best with cytotoxicity.

 

Vinblastine is a component of a number of chemotherapy regimens, including ABVD for Hodgkin lymphoma. It is also used to treat histiocytosis according to the established protocols of the Histiocytosis Association of America.

 
Package:
1kg/bag, 5kg/bag, 25kg/drum, double layers plastic bags inside.
 
Storage Situation:
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

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Ningbo Tianhong Biotech Co., Ltd.
Business Type
Manufacturer
Year Established
2010
Factory Size
1,000-3,000 square meters
Total Employees
51 - 100 People
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