Nicotinamide

CAS 98-92-0Introduction:Nicotinamide, also known as nicotinamide, vitamin B3 or vitamin PP, is a water-soluble vitamin that belongs to the B vitamins and is coenzyme I (nicotinamide adenine dinucleotide, NAD) and coenzyme II (nicotinamide adenine dinucleotide). The nicotinamide part of these two coenzyme structures in the human body has reversible hydrogenation and dehydrogenation properties. It plays a hydrogen transfer role in biological oxidation and can promote tissue respiration and biological oxidation. processes and metabolism, and are important in maintaining the integrity of normal tissues, especially the skin, digestive tract, and nervous system. When deficient, cell respiration and metabolism are affected, causing pellagra. Therefore, this product is mainly used to prevent and treat pellagra, stomatitis, glossitis, etc.Chemical properties:Niacinamide is a white needle-shaped crystal or crystalline powder, odorless or slightly smelly, with a slightly bitter taste. Relative density 1.4, melting point 129-131℃. 1g of this product is soluble in 1mL of water, 1.5mL of ethanol or 10mL of glycerol, but insoluble in ether. The pH of 10% aqueous solution is 6.5-7.5. Slightly hygroscopic. It is relatively stable and can withstand acid, alkali and high temperature. It is stable to light and heat in dry air. It generates nicotinic acid when heated in alkaline or acidic solution. The oral LD of rats is 2.5-3.5g/kg, and the ADI value is not specified (ECC, 1990).application:Niacinamide and niacin are commonly used in most combinations, and niacin also produces nicotinamide in animals. When the body lacks niacin and nicotinamide, pellagra can occur. Therefore they prevent pellagra. They play a role in protein and sugar metabolism and improve human and animal nutrition. In addition to being used as medicine, it is also widely used as food and feed additives.