Cosmetic Raw Material,allantoin,preservative,

Product Name: Allantoin Category: Cosmetic material Descriptions: INCI: Allantoin CAS: 97-59-6 EINECS: 202-592-8 Molecular Formula: C4H6N4O3 Molecular Weight: 158.12 Synonyms: 5-Ureidohydantoin;Glyoxylic acid diureide;2,5-Dioxo-4-imidazolidinyl urea Quality Specification: Properties Pharmaceutic Grade* Appearance White crystalline powder Odor Odorless Identification (a) IR Spectrum Conforms (b) TLC Test Conforms Content 98.5~101.0% Melting Point(with decomposition) 225℃ min. Loss on Drying 0.1% max. Residue on Ignition 0.1% max. pH (0.5% in water, 25℃) - Acidity or Alkalinity Conforms Optical Rotation Conforms Reducing Substances Conforms Related Substances Conforms As 0.0002% max. Pb 0.001% max. Conforms to USP,BP,EP Period of Validilty: 24 months Storage: Store in a well-ventilated, cool, dry area, out of direct sunlight. Keep containers tightly closed when not in use. Package: 25kg/drum Properties Solubility: Solubility in water increases obviously with increasing temperature (5.7g/L at 25℃;11g/L at 40℃;40g/L at 75℃). Slightly soluble in propylene glycol (3g/L at 25℃). Very slightly soluble in ethanol (0.4g/L at 25℃) and glycerin (0.15g/L at 25℃). Biological Activity : Allantoin promotes wound healing, speeds up cell regeneration, and has a keratolytic effect. It produces its desirable effects by promoting and speeding up the healthy, natural processes of the body. It helps the skin to help itself. Toxicological Data: Acute oral toxicity LD50 (rats): >5000mg/kg Eye irritation (rabbits): No irritation Skin irritation: Non-irritating at normal use levels Regulatory Status: In the USA: Not restricted in any way if used as a cosmetic ingredient. Classified by the FDA as a Category I (safe and effective), OTC drug (skin protectant) if used as an active ingredient. In the EU: (76/768/EEC) No direct regulations. No limitations; permitted for cosmetic use. In Japan: Not specifically regulated according to the Standards for Cosmetics, enacted by the Ministry of Health, Labour and Welfare. Applications: In pharmaceuticals and dermatology, allantoin is used in the treatment of ulcers, slow-healing wounds and burns. Addition of it to wound ointments and healing compositions promotes wound cleansing and healing. Allantoin has been classified by the US FDA OTC Topical Analgesic Review Panel as a Category I active ingredient (skin protectant), at use-levels of 0.5~2.0%. The FDA approved applications include minor cuts, scrapes, burns, sunburn, fever blisters, diaper rash and chafed, chapped, cracked or wind burned skin and lips. In cosmetics, allantoin is used in numerous preparations, where it enhances cell renewal, skin soothing, skin moisturizing, cleansing and healing action. In addition, it has the advantages of being non-toxic, non-irritating and effective in low concentrations. Allantoin promotes cell regeneration in skin exposed to and weakened by environmental factors, and helps to promote and maintain the health of intact skin on the body and face. Addition of it to hand lotions and hand creams helps eliminate rough, chapped skin, and leaves hands smooth and soft. In hair care, because of its extraordinarily good keratolytic properties, allantoin is a valuable additive in various products such as shampoos and hair gels, especially for the treatment of dandruff. Allantoin has been incorporated into various lotions and creams, lipsticks, aftershave balms, suntan products, bath foams, baby products and various aerosol preparations. It has also been used in oral hygiene products such as toothpaste and mouthwash. Its good compatibility with most relevant materials also allows it to be easily incorporated into existing formulations. The recommended use level in cosmetics is 0.1~0.5%.