Anti-cancer Docetaxel/ Taxotere 114977-28-5
Name: Docetaxel Powder
CAS No.114977-28-5
Molecular formula: C43H53NO14
Molecular weight: 807.88
Appesrsnce: White crystalline powder
Purity: 99%
Melting point: 232 ºC
alpha -36 º (c=0.74,EtOH)
Solubility: Insoluble in water; soluble in alcohol.
Product Source:Docetaxel is paclitaxel in the process of structural transformation of taxol from derivatives.
Docetaxel (Taxotere.) is a synthetic drug based on chemicals found in the yew tree. The drug's mechanism of action is similar to that of pacliltaxel in that it inhibits the breakdown of microtubules and inhibits cell division. Malignancies for which docetaxel is used include: Breast cancer (advanced or metastatic) Non-small cell lung cancer
Function
Docetaxel (trade name Taxotere) is a clinically well established anti-mitotic chemotherapy medication (that is, it interferes with cell division).Docetaxel is used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel has an FDA approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to stop cancer progression or relapsed. An European approval docetaxel for use in hormone-refractory prostate cancer. Docetaxel is considered better than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule.
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