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Name: Apigenin
Synonyms: 4′,5,7-Trihydroxyflavone
CAS Number: 520-36-5
Empirical Formula (Hill Notation): C15 H10 O5
Molecular Weight: 270.24
Beilstein Registry Number: 262620
MDL number: MFCD00006831
PubChem Substance ID: 24846790
EC Number: 208-292-3
Description
Biochem/physiol Actions: A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2 /M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibitory effects on tumor promotion may also be due to inhibition of kinase activity and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication.
Other Notes: Inhibitor of human estrogen synthetase1
Properties
product line BioChemika
assay ≥95.0% (HPLC)
total impurities ~2% water
mp >300 °C(lit.)
storage temp. −20°C
Safety
F 10
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS LK9276000
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