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Latin Name: Polygonum Cuspidatum
CAS No. : 501-36-0
Molecular Formula: C14H12O3
Grade Standard: Medicine Grade
Characters: Brown Powder
Used: Roots
Harvest time: Spring and Autumn
Active Ingredients: Resveratrol ,Trans-Resveratrol
Specification: 20%/10% by HPLC
Solubility: Soluble in water
Usage: Pharmaceuticals, healthcares, and cosmetics
Pharmacology:
In animal experiments, huzhang has exhibited antitussive, antihistaminic, hypotensive, vasodilating, cytotoxic, and antioxidant properties, among others. Huzhang is also a concentrated source of resveratrol (3,5,4¡Â-trihydroxy stilbene), an antioxidant phenol produced in response to fungi. Resveratrol has also shown antimutagenic activity in bioassays conducted on bacteria in vitro (umu and Ames tests). And, in a recent investigation conducted in vivo and in vitro, resveratrol displayed chemopreventive effects at three critical stages of carcinogenesis. Specifically, resveratrol was found to 1) induce phase II drug metabolizing enzymes (anti-initiation); 2) mediate anti-inflammatory effects and inhibit cyclooxygenase and hydro-peroxidase (antipromotion); and 3) induce human promyelocytic leukemia cell differentiation (anti-progression). Resveratrol was also found to inhibit the development of preneoplastic lesions in vitro and tumorigenesis in vivo. Very recently, it was reported that Huzhang extract is one of the best active-oxygen scavengers for the prevention of skin aging induced by UV-irradiation and free radical. Experiments conducted in vivo indicate that resveratrol is a potent vasodilator and inhibitor of platelet aggregation. Recent work in dogs and humans indicate that other concentrated sources of resveratrol (i.e., red wine and grape juice) eliminate cyclic blood-flow reductions caused by platelet-mediated thrombosis.
Active Compounds:
Huzhang is characterized by anthraquinones and their glycosides, napthoquinone, 3,5,4¡Â-trihydroxy stilbene (i.e. resveratrol), piceid, fallacinol, citreorosein, questin, questinol, protocatechuic acid, (+) catechin, 2,5-dimethyl-7- hydroxychromone, 7-hydroxy-4-methoxy-5-methylcoumarin, flavonols, polysaccharides, and condensed tannins.
Regulatory Status:
Under U.S. law, huzhang extract is regulated as a dietary supplement. As of this writing, no European governments had issued monographs or regulations for nutraceutical uses of huzhang. NOTE: The statements in this publication have not been evaluated by the FDA.
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