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Help CenterCyclopamine (11-deoxojervine)
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Botanical Resource: Veratrum californicum or Veratrum nigrum L
CAS No.: 4449-51-8
Molecular formula: C27H41NO2
Molecular weight: 411.62
Melting point: 237-238℃
Specific optical Rotation:[α]20℃D -44.2º
Product Specification 98% Cyclopamine (11-deoxojervine)
Physical Properties:
White Powder; Odorless; Melting point:237-238℃; Solubility:5mg·ml-1 Methanol;10mg·ml-1DMF.
Loss on drying: ≤0.5%
Physiological Functions & Applications
Cyclopamine inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the Smoothened protein.Cyclopamine is currently being investigated as a treatment agent in basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, tumors that result from excessive Hh activity [2], glioblastoma, and as a treatment agent for multiple myeloma.
HPLC-ELSD Chromatogram of 98% Cyclopamine
LC-MS of cyclopamine
H1-NMR of cyclopamine in CDCI3
C13-NMR of cyclopamine in CDCI3
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