Mucuna Pruriens
Specifications
M.pruriens seeds have antidepressant properties in cases of depressive neurosis when consumed and treatment of Parkinson diseaseMedicinal Uses
Traditionally, M. pruriens has been used as an effective aphrodisiac It is still used to increase libido in both men and women due to its dopamine inducing properties and in Ayurvedic medicine it is said to increase sperm count. Dopamine has a profound influence on sexual function. Use of Mucuna pruriens is well documented in Siddha medicine for a host of uses.
The plant and its extracts have been long used in tribal communities as a toxin antagonist for various snakebites. Research on its effects against Naja (Cobra),[9] Echis (Saw scaled viper),[10] Calloselasma (Malayan Pit viper) and Bangarus (Krait) [11] have shown that it has potential use in the prophylactic treatment of snakebites.
M.pruriens seeds have also been found to have antidepressant properties in cases of depressive neurosis when consumed.[12] and formulations of the seed powder have shown promise in the management and treatment of Parkinson disease .
Dried leaves of M.pruriens are sometimes smoked.[1] M.pruriens has also recently become popular among lucid dreaming enthusiasts: when combined with other supplements it stimulates the cholinergic system.
The hairs lining the seed pods and the small spicules on the leaves contain 5-hydroxytryptamine (serotonin) which cause severe itching (pruritus) when touched. The calyx below the flowers is also a source of itchy spicules and the stinging hairs on the outside of the seed pods are used in itching powder.[16]
Pharmacology
M.pruriens seeds contain high concentrations of levodopa, a direct neurotransmitter dopamine. It has long been used in traditional Ayurvedic Indian medicine for diseases including Parkinson's Disease. In large amounts (e.g. 30 g dose) it has been shown to be as effective as pure levodopa/carbidopa in the treatment of Parkinson's Disease, but no data on long-term efficacy and tolerability is available.
In addition to levodopa, it also contains serotonin (5-HT), 5-HTP, nicotine, N,N-DMT (DMT), bufotenine, and 5-MeO-DMT. As such, it could potentially have psychedelic effects, and it has purportedly been used in ayahuasca preparations.
The mature seeds of the plant contain about 3.1-6.1% L-DOPA,[14] with trace amounts of 5-hydroxytryptamine (serotonin), nicotine, DMT-n-oxide, bufotenine, 5-MeO-DMT-n-oxide, and beta-carboline.[22] One study using 36 samples of the seeds found no tryptamines present in them.[23]
The leaves contain about 0.5% L-DOPA, 0.006% dimethyltryptamine (DMT), 0.0025% 5-MeO-DMT and 0.003% DMT n-oxide.
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