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Specifications
IsoliquiritigeninLicorice Extract
Isoliquiritigenin CAS:961-29-5
English name:Isoliquiritigenin
Orginal plant: Glycyrrhizae root
Purity:HPLC98%
CAS NO. :961-29-5
Molecular formula:C15H12O4
Molecular weight:256.25
Quality data
Identification |
Standardization |
Aspect |
Brown yellow fine powder |
Odor & taste |
Characteristic |
Particle size |
NLT 95% through 80 meshes |
Loss on drying |
5.0% max. |
Sulphated ash |
5.0% max. |
Heavy metals |
20ppm max. |
Pb |
2ppm |
As |
2ppm |
Microbiological data
Total aerobic count |
Not more than 1000cfu/gram |
Yeast & Mold |
Not more than 100cfu/gram |
E. Coli |
Absence in 10g |
Salmonella |
Absence in 10g |
Addition data
Sterilization |
High temperature and press |
Storage |
Store in a cool dry place, avoiding sunlight directly |
Shelf life |
Two years when sealed well |
Packaging |
Food grade multiplayer polyethylene bags, 25kg in one type cardboard drum |
Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21CIP1/WAF1, a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer.
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