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Help CenterStandard Plant Extract Black Cohosh Extract With Triterpene Glycosides2.5~8 % Actaea Racemosa
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Black Cohosh Extract
Description
Actaea racemosa (black cohosh, black bugbane, black snakeroot,fairy candle; syn. Cimicifuga racemosa. Extracts from these plant materials are thought to possess analgesic, sedative, andanti-inflammatory properties.
Like most plants, black cohosh tissues and organs contain many organic compounds with biological activity. Estrogen-like compounds had originally been implicated in effects of black cohosh extracts on vasomotor symptoms in menopausal women.everal other studies, however, have indicated absence of estrogenic effects and compounds in black cohosh-containing materials. Recent findings suggest that some of the clinically relevant physiological effects of black cohosh may be due to compounds that bind and activate serotonin receptors, and a derivative of serotonin with high affinity to serotonin receptors, Nω-methylserotonin, has been identified in black cohosh. Complex biologicalmolecules, such as triterpene glycosides (e.g. cycloartanes), have been shown to reduce cytokine-induced bone loss (osteoporosis) by blocking osteoclastogenesis in in vitro and in vivo models. 23-O-acetylshengmanol-3-O-β-d-xylopyranoside, a cycloartane glycoside from Actaea racemosa, has been identified as a novel efficacious modulator of GABAA receptors with sedative activity in mice.
Latin name: Vernonia aspera(Roxb.) Buch.-Ham.
Description: The product is Cimicifuga Romose L. rhizome extract
Specifications: Black cohosh Cimicifugoside 40%, Raw powder, Ratio extract 4: 1-20: 1 etc.
Test Method: HPLC/TLC
Appearance: Brown powder
Functions
Historical use
Native Americans used black cohosh to treat gynecological and other disorders, including sore throats, kidney problems, and depression.Following the arrival of European settlers in the U.S. who continued the medicinal usage of black cohosh, the plant appeared in the U.S. Pharmacopoeia in 1830 under the name “black snakeroot”. In 1844 A. racemosa gained popularity when Dr. John King, an eclectic physician, used it to treat rheumatism and nervous disorders. Other eclectic physicians of the mid-nineteenth century used black cohosh for a variety of maladies, including endometritis, amenorrhea, dysmenorrhea, menorrhagia, sterility, severe after-birth pains, and for increased breast milk production.
Contemporary use
Black cohosh is used today mainly as a dietary supplement marketed to women as remedies for the symptoms ofpremenstrual tension, menopause and other gynecological problems. Recent meta-analysis of contemporary evidence supports these claims. Study design and dosage of black cohosh preparations play a role in clinical outcome, and recent investigations with pure compounds found in black cohosh have identified some beneficial effects of these compounds on physiological pathways underlying age-related disorders likeosteoporosis.
Applications
P.incarnata (maypop) leaves and roots have a long history of use among Native Americans in North Americaand were adapted by the European colonists. The fresh or dried leaves of maypop are used to make a tea that is used for insomnia, hysteria, and epilepsy, and is also valued for its analgesicproperties. P. edulis (passion fruit) and a few other species are used in Central and South America for similar purposes. Once dried, the leaves can also be smoked.
The medical utility of only a few species of Passiflora has been scientifically studied. In initial study in 2001 for treatment of generalized anxiety disorder, maypop extract performed as well as oxazepambut with fewer short-term side effects. It was recommended to follow up with long-term studies to confirm these results.
A study performed on mice demonstrated that Passiflora alata has a genotoxic effect on cells, and suggested further research was recommended before this one species is considered safe for human consumption.
Passionflower herb (Passiflorae herba) from P. incarnata is listed in the European Pharmacopoeia. The herbal drug should contain not less than 1.5% total flavonoids expressed as vitexin.
Passionflower is reputed to have sedative effects and has been used in sedative products in Europe, but in 1978, the U.S. Food and Drug Administration prohibited its use in over-the-counter sedative preparations because it had not been proven safe and effective. In 2011, the University of Maryland Medical Center reported that passionflower "... can trigger side effects and can interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider."
(1).Packing Detail: 25kg/drum OR 1kg/bag (1kg net weight, 1.2kg gross weight, packed in a plastic bag) OR as per your request;
(2).Storage Situation: Stored in a cool and dry wellclosed container kept away from moisture and strong light or high temperature;
(3).Shelf Life: Two years under well Storage situation and stored away from direct sun light.
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