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Synonyms:Hyaluronic Acid, Sodium Hyaluronate, Hyaluronan,HA;
Production method: Microbial fermentation method
CAS No.: 9067-32-7
Molecular formula: (C14H20NO11Na)n
Molecular Structure:
Appearance: White or off white powder
Quality Standard & Grade:
1. Cosmetic grade
2. Food grade
3. Pharmaceutical Grade
4. Injection Grade
Product Specification (Classification of HA according to molecular weight):
• High molecular weight Sodium Hyaluronate (HA)--- Above 1.8M Da.
• Medium molecular weight Sodium Hyaluronate (HA)--- 1.0-1.8M Da
• Low molecular weight Sodium Hyaluronate (HA)--- Less than 1.0M Da.
• Oligosaccharide Hyaluronic Acid--- Less than 10k Da.
Product Introduction
Sodium Hyaluronate (Hyaluronic acid,HA), the sodium salt of Hyaluronic acid, is a linear high molecular weight mucopolysaccharide composed by thousands of repeating disaccharide units of D-glucuronic acid and N-ACETYL-D-glucosamine. s,with the molecular weight of 10 k ~ 4 million Dalton. It widely exists in the extra-cellular matrix (ECM) of human and vertebrate tissues and the capsules of some streptococcus, has important physiological functions. Hyaluronic acid has excellent compatibility and can be added into almost all kinds of Cosmetic products. However, because of its characteristic of big molecule chemical structure and having high viscosity, the dissolution process is relatively slow. Usually the higher the molecular weight, the more time it takes before complete dissolution.
Functions of HA
• A component of matrix: HA is major component of intercellular and extracellular matrix. It plays an important role in maintenance of normal structure and function of cells.
• Intelligent moisturizing effect:HA can adjust moisture according to relative environmental humidity.
• Lubrication:HA can help support joint function.
• Functions to cells:HA can influence migration, hyperplasia and differentiation of cells.
• Facilitating wound healing: HA can facilitate scar-free wound healing
Applications
- Cosmetics: moisturizing.
- Pharmaceutical area: Used as viscoelastic substance in ophthalmic surgery, articular injection and as prevention agent of postoperative adhesions based on its viscoelastic property.
Attention for chemical incompatibility
HA is a kind of large molecule polyanion polysaccharides, during dissolution process please avoid using it together with cation emulgator or cation preservatives. Failure to do so may results in turbid or precipitation.
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