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Name: Salicylic acid |
Chemical Fomula: C6H4(OH)(COOH) |
SMILES: O=C(O)c1ccccc(O)c1 |
CAS No.: 69-72-7 |
Appearance: Crystalline powder |
Mole Mass: 138.121 g·mol−1 |
Flashing point: 157℃ |
Density: 1.44 g/cm3 (20℃) |
Melting point: 158-161℃ |
Boiling point: 211℃ |
Properties: white crystalline powder
Solubility: Slightly soluble in water, soluble in organic solvents.
The external use of salicylic acid for anti-acne composition is recognized as safe in the world.
The clinical test results of salicylic acid products
Salicylic acid Efficacy summary
Anti-inflammatory effect
Remove horny, promote skin metabolism, and brighten skin tone
Anti-aging effect
The problems with Salicylic acid direct application
Salicylic acid is a fat soluble substance, which has a strong irritant to the skin. So its application is limited.
In the finished product formula, the salicylic acid is easy to crystallize, thus affecting the quality of the product.
Excellent anti acne products
The use of the world's leading Lipid Nanoparticles technology, to encapsulating salicylic acid.
Lipid Nanoparticles (LNP)
Lipid nanoparticles is a new type of sub micro drug delivery system, which using natural or synthetic lipids as base material to encapsulating the activity substance in lipid capsule, made of particle size of 50~1000nm lipid particle drug delivery system, solves the shortcomings of instability of general lipid in vivo and in vitro, avoid the instabilities as a drug carrier system. Therefore, it is not only favor by the medical profession, but also gradually applied to the cosmetics industry in recent years
Composition table of salicylic acid NP
Item |
Content % |
Caprylic/ Capric Triglyceride: |
5-20 |
Ethoxydiglycol |
1-10 |
Salicylic acid |
10 |
PEG-30 Dipolyhydroxystearate |
5-25 |
Laureth-23 |
1-10 |
EMPILAN KM 25 |
1-10 |
|
Caprylic/ Capric Triglyceride PEG-8 Caprylic/ Capric Glycerides |
1-10 |
Water |
15-55 |
Solving the irritation problem
Patch test for 0.03ml 0.8% salicylic acid vs 0.8% salicylic acid NP
The patch test result
The experimental result showed that the irritation of the encapsulated salicylic acid NP is greatly reduced.
Solution crystallization problem
The salicylic acid NP can mix with any proportion of water.
Effect of pH on salicylic acid
The experimental results show that: pH has little effect on the appearance of aqueous solution of salicylic acid.NP.
5% salicylic acid +KOH
Therefore, it is suggested that the amount of KOH 0.1M added in the proposed formula is 10%~40%.
10% salicylic acid +KOH
Therefore, it is suggested that the amount of KOH 0.1M added in the proposed formula is 10%~70%
Recommended formula Guide
Solubility: dispersed in room temperature water, and then can be added to the formula in any proportion.
PH value: facial mask products, recommended pH 5.5 - 6; emulsion, essence, water and water products, the proposed pH 4.5 - 5.5.
Added amount: facial mask products, recommended to add the amount of 1%-5%, the cream of the cream essence products recommended to add the amount of 1%-10%.
Preservation: avoid light preservation, the use of opaque materials.
John FENG: unicorn_cn at hotmail dot com
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